Laureates of the interdisciplinary call 2022

Projects funded in 2022

• Laurent Bourdieu (ENS-IBENS), Thomas Pons (ESPCI-LPEM), Nicolas Lequeux (ESPCI, LPEM) and Alexandra Fragola (Université Paris Saclay - ISMO) - Two-photon functional neuroimaging using Quantum Dot based Adaptive Optics I Optical recording of neuronal activity in deep cortical layers is challenging due to scattering and aberrations. By combining innovative adaptive optics methods with new fluorescent quantum dots, we aim at recording the neuronal activity in the deepest cortical layers to study sensory coding in mice.

• Charlie Gosse (IBENS), Laurent Catoire (IBPC), Guillaume Stirnemann (IBPC) and Jean-Louis Banères (IBMM) - Probing the allosteric regulation of binding by singlemolecule force spectroscopy I Cellular receptors called GPCRs work like information relays, interacting for instance with
  hormones and signaling proteins. We aim at deciphering how drugs modulate the behavior of
  these relay by binding to them and acting from a distance on their association with their partners.

• Pierre-Yves Plaçais (ESPCI) and Auguste Genovesio (IBENS) - Metabolic underpinning of aging-induced memory deficits revealed by brain label-free fluorescence lifetime imaging I Aging differentially affects the various types of memory the brain can encode. Combining an innovative in vivo metabolic imaging technique with the development of a deep-learning based analysis procedure, we will unveil the metabolic traits that make specific brain circuits prone to dysfunction during aging.

• Vincent Semetey (Chimie ParisTech) and Sylvie Coscoy (Institut Curie) - Endothelial engagement in 3D chiral microenvironments I Our project aims to understand the fine mechanisms regulating the interaction of blood vessel cells with their fibrous environment. It investigates with high resolution 3D printing the geometrical features, including new asymmetrical aspects, involved in blood vessel pathophysiology.